幹細胞、幹細胞培養上清（StemSup）に関係した論文
Terunuma A, Yoshioka Y, Sekine T, Takane T, Shimizu Y, Narita S, Ochiya T, Terunuma H., Extracellular vesicles from mesenchymal stem cells of dental pulp and adipose tissue display distinct transcriptomic characteristics suggestive of potential therapeutic targets. Journal of Stem Cells and Regenerative Medicine. 17(2):56-60, 2021
PMID: 35250202
Terunuma A, Ashiba K, Takane T, Sakaguchi Y, Terunuma H., Comparative transcriptomic analysis of human mesenchymal stem cells derived from dental pulp and adipose tissues. Journal of Stem Cells and Regenerative Medicine. 15(1):1-4, 2019
PMID: 31239606
Terunuma H, Ashiba K, Terunuma A, Deng X, Watanabe K., Conditioned medium of human immor talized mesenchymal stem cells as a novel therapeutic tool to repair damaged tissues. Journal of Neuroscience and Neuroengineering. 4:9-12, 2017
DOI: 10.1166/jnsne.2017.1107
Ashiba K, Terunuma A, Terunuma H, Takane T, Deng X, Yamashita Y, Watanabe K., Immortalized mesenchymal stem cells producing conditioned medium in a large scale for therapeutic usage. Inflammation Regeneration. 35:63-66, 2015
Free Article
アンチエイジングに関係した論文
Deng X, Terunuma H., Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics. Immunity & Ageing. 21 Article number: 43, 2024
https://immunityageing.biomedcentral.com/articles/10.1186/s12979-024-00451-2
再生医療に関係した論文
Ashiba K, Mino K, Okido Y, Sato K, Kawakami H., Senescence recovering by dual drug-encapsulated liposomal nanoparticles for large-scale human cell expansion. Journal of Artificial Organs. 26:246-250, 2023
PMID:35984542
Mizutani M, Terunuma H, Samejima H, Ashiba K, Kino-oka M., Variation in the manufacturing reproducibility of autologous cell-based products depending on raw material shipment conditions. Regenerative Therapy. 12:102-107, 2019
PMID:31890773
鮫島葉月,水谷学: CPCにおける新GMP対応のポイント.「iPS細胞の安全・高品質な作製技術」技術情報協会: 304-308 (2016)
Mizutani M, Samejima H, Terunuma H, Kino-oka M., Experience of contamination during autologous cell manufacturing in cell processing facility under the japanese medical practitioners act and the medical care act. Regenerative Therapy. 5:25–30, 2016
PMID:31245497
鮫島葉月: 製造工程のプロセス評価／検証と工程内管理試験の設定. 「再生医療における臨床研究と製品開発」 技術情報協会: 496-499 (2013)
鮫島葉月: マイコプラズマ否定試験迅速法の可能性. 「幹細胞医療の実用化技術と産業展望」 シーエムシー出版: 262-266 (2013)
Osawa H, Orii K, Terunuma H, Abraham SJK., Combining autologous peripheral blood mononuclear cells with fibroblast growth factor therapy along with stringent infection control leading to successful limb salvage in diabetic patient with chronic renal failure and severe toe gangrene. Int J Stem Cells. 7:158-161, 2014
PMID: 25473454
がん治療に関係した論文
Deng X, Terunuma H., Harnessing NK Cells to Control Metastasis. Vaccines. 10(12):2018, 2022
DOI: 10.3390/vaccines10122018
Deng X, Terunuma H, Nieda M., Exploring the utility of NK cells in COVID-19. Biomedicines. 10:1002-1021, 2022
DOI: 10.3390/biomedicines10051002
Enomoto A, Fukasawa T, Terunuma H, Nakagawa K, Yoshizaki A, Sato S, Miyagawa K., Decrease in MAP3Ks expression enhances the cell death caused by hyperthermia. International Journal of Hyperthermia. 39(1):200-208, 2022
DOI: 10.1080/02656736.2021.2024281
Deng X, Terunuma H, Nieda M., Immunosurveillance of cancer and viral infections with regard to alterations of human NK cells Originating from lifestyle and aging. Biomedicines. 9:557-570, 2021
DOI: 10.3390/biomedicines9050557
照沼裕 (Terunuma H): がん治療における口腔健康管理の重要性 (Dental health management of cancer patients). 老年歯科医学, 34:441-444 (2020)
DOI: 10.11259/jsg.34.441
Mizutani M, Terunuma H, Samejima H, Ashiba K, Kino-oka M., Variation in the manufacturing reproducibility of autologous cell-based products depending on raw material shipment conditions. Regenerative Therapy. 12:102-107, 2019
PMID:31890773
Yagi M, Terunuma H, Eiraku Y, Deng X, Nieda M., Induction of cytomegalovirus pp65-specific CD8+T cells in vivo following administration of autologous tumor lysate-pulsed dendritic cells, coplused with zoledronate and α-galactosylceramide in a patient with glioblastoma multiforme. Clinical Research in Immunology. 1:1-5, 2018
Free Article
Eiraku Y, Terunuma H, Yagi M, Deng X, Nicol AJ, Nieda M., Dendritic cells cross-talk with tumour antigen-specific CD8+ T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors. Clinical & Experimental Immunology. 194:54–66, 2018
AID - CEI13185
Chidambaram R, Terunuma H, Balamurugan M, Dedeepiya YD, Sumana P, Senthilkumar R, Rajmohan M, Karthick R, Preethy S and Abraham SJK., Cell‑based immunotherapy in stage IIIA inflammatory breast cancer with declining innate immunity following successive chemotherapies: A case report. Mol Clin Oncol. 7:493-497, 2017
DOI: 10.3892/mco.2017.1333
Preethy S, Dedeepiya VD, Senthilkumar R, Rajmohan M, Karthick R, Terunuma H, Abraham SJK., Natural killer cells as a promising tool to tackle cancer - A review of sources, methodologies, and potentials. International Reviews of Immunology. 36(4):220-232, 2017
PMID:28471248
Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ., Dendritic cells cross talk with cytomegalovirus pp65-specific cytotoxic T cells, Vγ9γδT cells, and invariant NKT cells in patients with glioblastoma multiforme. In: Hiroto S. Watanabe, editor. Horizons in Cancer Research, volume 63. New York, Nova Science Publisher, Inc.; (2016) pp93-118
Terunuma H., Potentiating immune system by hyperthermia. In: Kokura S, Yoshikawa T, OhnishiT, Editors. Hyperthermic oncology from bench to bedside. Springer Nature; (2016) pp127-135
Terunuma H, Nishino N, Abe T, Yoshimura A, Toki A, Ishiguro T, Deng X, Terunuma A., Combining hyperthermia and immunotherapy: NK Therapy and Hyperthermia. In: Kokura S, Yoshikawa T, OhnishiT, Editors. Hyperthermic Oncology from Bench to Bedside. Springer Nature; (2016) pp309-318
照沼裕、芦葉恵介、鄧学文、茂野淳平、高根翼、鮫島葉月、照沼篤. 活性化NK細胞の大量培養法の開発とその有効利用の可能性(Generating large numbers of activated natural killer (NK) cells and their utility in cancer therapy). BIO Clinica, 31:55-61 (2016) [Japanese].
Abraham SJK, Terunuma H, Dedeepiya VD, Premkumar S, Preethy S., An overview of treatment for cervical cancer with emphasis on immune cell-based therapies. In: de Mello RA, Tavares A, Mountzios G, editors. International Manual on Oncology Practice. London, Springer International Publishing AG Switzerland, Inc.; (2015) pp933-954
鄧学文、芦葉恵介、照沼篤、高根翼、鮫島葉月、贄田美江、照沼裕: 培養NK細胞の投与による体内NK細胞の活性化. Medical Science Digest, 41:42-45 (2015)
Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ., Preferential expansion of Th1 type-CD56+Vγ9γδT cells by CD56high+IFNα-induced dendritic cells derived from cancer patients in vitro and in vivo. Int J Immunol Immunother. 2:1-8, 2015
doi.org/10.23937/2378-3672/1410005
Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Effective induction of melanoma-antigen-specific CD8+ T cells via Vγ9γδT cell expansion by CD56high+ interferon-a-induced dendritic cells. Experiment Dermatol. 24:35-41, 2015
PMID: 25363560
Deng X, Terunuma H, Terunuma A, Takane T, Nieda M: Ex vivo - expanded natural killer cells kill cancer cells more effectively than ex vivo -expanded γδ T cells or αβ T cells. Int Immunopharmacol. 22:486-491, 2014
PMID: 25131561
Raj R, Deenadayalan M, Kumar GV, Khandelwal V, Sri K, Senthilkumar R, Abraham SJK, Terunuma H., Autologous immune enhancement therapy in Philadelphia chromosome positive acute lymphoblastic leukemia. Indian J Hematol Blood Transfus, Issue 1 supplement. 30:202-204, 2014
PMID: 25332578
Bhamare S, Prabhakar P, Dharmadhikari A, Dedeepiva VD, Terunuma H, Senthilkumar R, Srinivasan T, Reena HC, Abraham SJ., Autologous immune enhancement therapy in a case of gall bladder cancer stage IV after surgical resection and chemotherapy yielding a stable non-progressive disease. J Cancer Res Ther. 10:752-754, 2014
PMID: 25313776
Terunuma H, Deng X, Nishino N, Watanabe K., NK cell-based autologous immune enhancement therapy (AIET) for cancer. Stem Cells Regenerative Med. 9:9-13, 2013
PMID: 24693203
Subramani B, Ratnavelu K, Pullai CR, Krishnan K, Sugadan SD, Deng X, Terunuma H., Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncol Lett 5:1611-1614, 2013
PMID: 23761827
Preethy S, John S, Ganesh SJ, Srinivasan T, Terunuma H, Iwasaki M, Abraham SJK., Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives. Stem cells and Cloning: Advances and Applications. 6:13-18, 2013
PMID: 24426785
Deng X, Terunuma H, Nieda M, Xiao W, Nicol A., Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. Int Immunopharmacol. 14:593-605, 2012
PMID: 23063974
Manjunath SR, Ramanan G, Dedeepiya VD, Terunuma H, Deng X, Baskar S, Senthilkumar R, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJ., Autologous immune enhancement therapy in recurrent ovarian cancer with metastases: a case report. Case Rep Oncol. 5(1):114-118, 2012
PMID: 22666198
Terunuma H, Deng X, Toki A, Yoshimura A, Nishino N, Takano Y, Nieda M, Sasanuma J, Teranishi Y, Watanabe K., Effects of hyperthermia on the host immune system: from NK cell-based science to clinical application. Thermal Med. 28:1-9, 2012
Dedeepiya VD, Terunuma H, Deng X, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJK., A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anemia and ovarian cancer with patients with other solid tumours. Oncol letters. 3:435-440, 2012
PMID: 22740927
Takada M, Terunuma H, Deng X, Dewan MZ, Saji S, Kuroi K, Yamamoto N, Toi M., Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach. Breast Cancer. 18:64-67, 2011
PMID: 20354831
Dewan MZ, Takada M, Terunuma H, Deng X, Ahmed S, Yamamoto N, Toi M., Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomed Pharmacother. 63:703-706, 2009
PMID:19269774
照沼裕, トウ学文：自己活性化NK細胞を用いた免疫細胞療法．Biotherapy, 22:327-331 (2008)
照沼裕：制御性T細胞と温熱. 吉川敏一監修, 古倉聡編集 がんの温熱免疫療法 ― ハイパーサーミック・イムノロジー ―. 診断と治療社（東京） (2008) pp43-47,
Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N., Potential role of NK cells in the induction of immune responses: Implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol. 27:93-110, 2008
PMID: 18437601
照沼裕, 他：細胞免疫療法 [Immune cell therapy]. 治療 [Chiryou], 89:1525-1532 (2007)
Terunuma H, Wada A, Deng X, Yasuma Y, Onishi T, Toki A, Abe H., Mild hyperthermia modulates the relative frequency of lymphocyte cell subpopulations: an increase in a cytolytic NK cell subset and a decrease in a regulatory T cell subset. Thermal Medicine. 23:41-47, 2007
Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N., Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res Treat. 104:267-275, 2007
PMID: 17066321
Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N., Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci. 97:1381-1387, 2006
PMID: 16995875
照沼裕：温熱療法と免疫療法 [Hyperthermia and immunotherapy]. 日本ハイパーサーミア誌 [Thermal Medicine] 22:105-106 (2006)
Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M, Yamamoto N., Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomedicine & Pharmacotherapy. 59:S375-S379, 2005
PMID: 16507413
Kawamura M, Kasai H, He L, Deng X, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M., Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology. 114:397-409, 2005
PMID: 15720441
感染症に関係した論文
Sakurai D, Iwatani Y, Ohtani H, Naruse KT, Terunuma H, Sugiura W, Kimura A: APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics. 67:253-257, 2015
PMID: 25721876
Nakayama EE, Nakajima T, Kaur G, Mimaya J, Terunuma H, Mehra N, Kimura A, Shioda T: A naturally occurring single amino acid substitution in human TRIM5a linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection. AIDS Research Hum Retroviruses. 29:919-924, 2013
PMID: 23379364
Itaya S, Nakajima T, Kaur G, Terunuma H, Ohtani H, Mehra N, Kimura A., No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. J Infect Dis. 202:815-816, 2010
PMID: 20684727
Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya JI, Ohtani H, Mehra N, Shioda T, Kimura A., Impact of novel TRIM5α variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS. 23:2091-2100, 2009
PMID: 19710594
Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya JI, Terunuma H, Kimura A., Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics. 59:793-798, 2007
PMID: 17874089
Hoshino S, Sun B, Konishi M, Shimura M, Segawa T, Hagiwara Y, Koyanagi Y, Iwamoto A, Mimaya J, Terunuma H, Kano S, Ishizaka Y., Vpr in plasma of HIV type 1-positive patients is correlated with the HIV type 1 RNA titers. AIDS Research Hum Retroviruses. 23:391-397, 2007
PMID: 17411372
照沼裕：NK細胞とHIV [NK cell and HIV]. 日本エイズ学会学会誌 [The Journal of AIDS Research], 8:21-24 (2006)
照沼裕：アフリカ・ザンビア国のエイズの現状. 福島医学雑誌 56:39-40 (2006)
Munkanta M, Terunuma H, Takahashi M, Hanabusa H, Miura T, Ikeda S, Sakai M, Fujii T, Takahashi Y, Oka S, Matsuda J, Ishikawa M, Taki M, Takashima Y, Mimaya J, Ito M, Kimura A, Yasunami M., HLA-B polymorphism in Japanese HIV-1-infected long-term surviving hemophiliacs. Viral Immunology. 18:500-505, 2005
PMID: 16212528
Munkanta M, Handema R, Kasai H, Gondwe C, Deng X, Yamashita A, Asagi T, Yamamoto N, Ito M, Kasolo F, Terunuma H., Predominance of 3 NF-kB binding sites in the long terminal repeat region of HIV type 1 subtype C isolates from Zambia. AIDS Research and Human Retroviruses. 21:901-906, 2005
PMID: 16225420
Kankasa C, Siwale M, Kasolo F, Nishiyama A, Terunuma H, Wakasugi N., Socioeconomic and reproductive factors associated with condom use within and outside of marriage among urban pregnant women in Zambia. Afr J Reprod Health. 9:128-136, 2005
PMID: 16623197
Mitarai S, Kafwabulula LM, Habeenzu C, Terunuma H, Lubasi D, Kasolo F, Shishido H, Numazaki Y., Mycobacterium tuberculosis and gyrA variation in Zambia. Tropical Medicine and Health. 33:91-94, 2005