学術情報


<再生医療/幹細胞培養上清(再生因子)に関係した論文>

Terunuma H, Ashiba K, Terunuma A, Deng X, Watanabe K: Conditioned medium of human immortalized mesenchymal stem cells as a novel therapeutic tool to repair damaged tissues. Journal of Neuroscience and Neuroengineering, 4, 9-12(4) , 2017

鮫島葉月,水谷学: CPCにおける新GMP対応のポイント.「iPS細胞の安全・高品質な作製技術」技術情報協会: 304-308,2016

Mizutani M, Samejima H, Terunuma H, Kino-oka M: Experience of contamination during autologous cell manufacturing in cell processing facility under the japanese medical practitioners act and the medical care act. Regenerative Therapy, 5:25–30,2016
Free Article

Ashiba K, Terunuma A, Terunuma H, Takane T, Deng X, Yamashita Y, Watanabe K: Immortalized mesenchymal stem cells producing conditioned medium in a large scale for therapeutic usage. Inflammation Regeneration, 35: 63-66, 2015
Free Article

Osawa H, Orii K, Terunuma H, Abraham SJK: Combining autologous peripheral blood mononuclear cells with fibroblast growth factor therapy along with stringent infection control leading to successful limb salvage in diabetic patient with chronic renal failure and severe toe gangrene. Int J Stem Cells 7: 158-161, 2014
PMID: 25473454

鮫島葉月: 製造工程のプロセス評価/検証と工程内管理試験の設定. 「再生医療における臨床研究と製品開発」 技術情報協会: 496-499, 2013

鮫島葉月: マイコプラズマ否定試験迅速法の可能性. 「幹細胞医療の実用化技術と産業展望」 シーエムシー出版: 262-266, 2013


<がん免疫療法に関係した論文>
Chidambaram R, Terunuma H, Balamurugan M, Dedeepiya YD, Sumana P, Senthilkumar R, Rajmohan M, Karthick R, Preethy S and Abraham SJK: Cell‑based immunotherapy in stage IIIA inflammatory breast cancer with declining innate immunity following successive chemotherapies: A case report. Mol Clin Oncol 7: 493-497, 2017
DOI: 10.3892/mco.2017.1333

Preethy S, Dedeepiya VD, Senthilkumar R, Rajmohan M, Karthick R, Terunuma H, Abraham SJK: Natural killer cells as a promising tool to tackle cancer - A review of sources, methodologies, and potentials. International Reviews of Immunology, 2017
DOI:10.1080/08830185.2017.1284209

Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Dendritic cells cross talk with cytomegalovirus pp65-specific cytotoxic T cells, Vγ9γδT cells, and invariant NKT cells in patients with glioblastoma multiforme. In: Hiroto S. Watanabe, editor. Horizons in Cancer Research, volume 63. New York, Nova Science Publisher, Inc.; 2016. pp93-118

Terunuma H: Potentiating immune system by hyperthermia. In: Kokura S, Yoshikawa T, OhnishiT, Editors. Hyperthermic Oncology from Bench to Bedside. Springer Nature; 2016. pp127-135

Terunuma H, Nishino N, Abe T, Yoshimura A, Toki A, Ishiguro T, Deng X, Terunuma A: Combining hyperthermia and immunotherapy: NK Therapy and Hyperthermia. In: Kokura S, Yoshikawa T, OhnishiT, Editors. Hyperthermic Oncology from Bench to Bedside. Springer Nature; 2016. pp309-318

照沼裕、芦葉恵介、鄧学文、茂野淳平、高根翼、鮫島葉月、照沼篤 (Terunuma H, Ashiba K, Deng X, Shigeno J, Takane T, Samejima H, Terunuma A): 活性化NK細胞の大量培養法の開発とその有効利用の可能性(Generating large numbers of activated natural killer (NK) cells and their utility in cancer therapy). BIO Clinica 31: 55-61, 2016 [Japanese].

Abraham SJK, Terunuma H, Dedeepiya VD, Premkumar S, Preethy S: An overview of treatment for cervical cancer with emphasis on immune cell-based therapies. In: de Mello RA, Tavares A, Mountzios G, editors. International Manual on Oncology Practice. London, Springer International Publishing AG Switzerland, Inc.; 2015. pp933-954

鄧学文、芦葉恵介、照沼篤、高根翼、鮫島葉月、贄田美江、照沼裕: 培養NK細胞の投与による体内NK細胞の活性化. Medical Science Digest 41, 42-45, 2015

Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Preferential expansion of Th1 type-CD56+Vγ9γδT cells by CD56high+IFNα-induced dendritic cells derived from cancer patients in vitro and in vivo. Int J Immunol Immunother 2, 1-8, 2015

Nieda M, Terunuma H, Eiraku Y, Deng X, Nicol AJ: Effective induction of melanoma-antigen-specific CD8+ T cells via Vγ9γδT cell expansion by CD56high+ interferon-a-induced dendritic cells. Experiment Dermatol 24, 35-41, 2015
PMID: 25363560

Subramani B, Pullai CR, Krishnan K, Sugadan SD, Deng X, Terunuma H and Ratnavelu K: Efficacy of ex vivo activated and expanded natural killer cells and T lymphocytes for colorectal cancer patients. Biomed Rep 2: 505-508, 2014
PMCID: PMC4051481

Deng X, Terunuma H, Terunuma A, Takane T, Nieda M: Ex vivo - expanded natural killer cells kill cancer cells more effectively than ex vivo -expanded γδ T cells or αβ T cells. Int Immunopharmacol 22: 486-491, 2014
PMID: 25131561

Raj R, Deenadayalan M, Kumar GV, Khandelwal V, Sri K, Senthilkumar R, Abraham SJK, Terunuma H: Autologous immune enhancement therapy in Philadelphia chromosome positive acute lymphoblastic leukemia. Indian J Hematol Blood Transfus, Issue 1 supplement 30: 202-204, 2014
PMID: 25332578

Bhamare S, Prabhakar P, Dharmadhikari A, Dedeepiva VD, Terunuma H, Senthilkumar R, Srinivasan T, Reena HC, Abraham SJ: Autologous immune enhancement therapy in a case of gall bladder cancer stage IV after surgical resection and chemotherapy yielding a stable non-progressive disease. J Cancer Res Ther 10: 752-754, 2014
PMID: 25313776

Terunuma H, Deng X, Nishino N, Watanabe K: NK cell-based autologous immune enhancement therapy (AIET) for cancer. Stem Cells Regenerative Med 9: 9-13, 2013
PMID: 24693203

Subramani B, Ratnavelu K, Pullai CR, Krishnan K, Sugadan SD, Deng X, Terunuma H: Autologous immune enhancement therapy: A case report of a stage IV colonic cancer. Oncol Lett 5: 1611-1614, 2013
PMID: 23761827

Ratnavelu K, Subramani B, Pullai CR, Krishnan K, Sugadan SD, Rao MS, Veerakumarasivam A, Deng X, Terunuma H: Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report. Oncol Lett 5: 1457-1460, 2013
PMID: 23761810

Preethy S, John S, Ganesh SJ, Srinivasan T, Terunuma H, Iwasaki M, Abraham SJK: Age-old wisdom concerning cell-based therapies with added knowledge in the stem cell era: our perspectives. Stem cells and Cloning: Advances and Applications 6: 13-18, 2013
PMID: 24426785

Premkumar S, Dedeepiya VD, Terunuma H, Senthilkumar R, Srinivasan T, Reena HC, Preethy S, Abraham SJK: Cell based autologous immune enhancement therapy (AIET) after radiotherapy in a locally advanced carcinoma of the cervix. Case Reports in Oncological Medicine Article ID 903094, http://dx.doi.org/10.1155/2013/903094, 2013
PMID: 23653878

Deng X, Terunuma H, Nieda M, Xiao W, Nicol A: Synergistic cytotoxicity of ex vivo expanded natural killer cells in combination with monoclonal antibody drugs against cancer cells. Int Immunopharmacol 14: 593-605, 2012.
PMID: 23063974

Manjunath SR, Ramanan G, Dedeepiya VD, Terunuma H, Deng X, Baskar S, Senthilkumar R, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJ: Autologous immune enhancement therapy in recurrent ovarian cancer with metastases: a case report. Case Rep Oncol. 2012 Jan; 5(1): 114-8, 2012.
PMID: 22666198

Terunuma H, Deng X, Toki A, Yoshimura A, Nishino N, Takano Y, Nieda M, Sasanuma J, Teranishi Y, Watanabe K: Effects of hyperthermia on the host immune system: from NK cell-based science to clinical application. Thermal Med 28: 1-9, 2012.

Dedeepiya VD, Terunuma H, Deng X, Baskar S, Manjunath SR, Senthilkumar R, Murugan P, Thamaraikannan P, Srinivasan T, Preethy S, Abraham SJK: A comparative analysis of in vitro expansion of natural killer cells of a patient with autoimmune haemolytic anemia and ovarian cancer with patients with other solid tumours. Oncol letters 3: 435-440, 2012.
PMID: 22740927

Takada M, Terunuma H, Deng X, Dewan MZ, Saji S, Kuroi K, Yamamoto N, Toi M: Refractory lung metastasis from breast cancer treated with multidisciplinary therapy including an immunological approach. Breast Cancer 18: 64-67, 2011.
PMID: 20354831

Dewan MZ, Takada M, Terunuma H, Deng X, Ahmed S, Yamamoto N, Toi M: Natural killer activity of peripheral-blood mononuclear cells in breast cancer patients. Biomed Pharmacother 63: 703-706, 2009.
PMID:19269774

照沼裕, トウ学文:自己活性化NK細胞を用いた免疫細胞療法.Biotherapy 22: 327-331, 2008.

照沼裕:制御性T細胞と温熱. 吉川敏一監修, 古倉聡編集 がんの温熱免疫療法 ― ハイパーサーミック・イムノロジー ―. 診断と治療社(東京), 2008. pp43-47,

Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N: Potential role of NK cells in the induction of immune responses: Implications for NK cell-based immunotherapy for cancers and viral infections. Int Rev Immunol 27: 93-110, 2008.
PMID: 18437601

照沼裕, 他:細胞免疫療法 [Immune cell therapy]. 治療 [Chiryou] 89: 1525-1532, 2007.

Terunuma H, Wada A, Deng X, Yasuma Y, Onishi T, Toki A, Abe H: Mild hyperthermia modulates the relative frequency of lymphocyte cell subpopulations: an increase in a cytolytic NK cell subset and a decrease in a regulatory T cell subset. Thermal Medicine 23: 41-47, 2007.

Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N: Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res Treat 104: 267-275, 2007.
PMID: 17066321

Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N: Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci 97: 1381-1387, 2006.
PMID: 16995875

照沼裕:温熱療法と免疫療法 [Hyperthermia and immunotherapy]. 日本ハイパーサーミア誌 [Thermal Medicine] 22: 105-106, 2006.

Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M, Yamamoto N: Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomedicine & Pharmacotherapy 59: S375-S379, 2005.
PMID: 16507413

Kawamura M, Kasai H, He L, Deng X, Yamashita A, Terunuma H, Horiuchi I, Tanabe F, Ito M: Antithetical effects of hemicellulase-treated Agaricus blazei on the maturation of murine bone-marrow-derived dendritic cells. Immunology 114: 397-409, 2005.
PMID: 15720441


<感染症に関係した論文>


Sakurai D, Iwatani Y, Ohtani H, Naruse KT, Terunuma H, Sugiura W, Kimura A: APOBEC3H polymorphisms associated with the susceptibility to HIV-1 infection and AIDS progression in Japanese. Immunogenetics 67: 253-257, 2015
PMID: 25721876

Nakayama EE, Nakajima T, Kaur G, Mimaya J, Terunuma H, Mehra N, Kimura A, Shioda T: A naturally occurring single amino acid substitution in human TRIM5a linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection. AIDS Research Hum Retroviruses 29: 919-924, 2013
PMID: 23379364

Itaya S, Nakajima T, Kaur G, Terunuma H, Ohtani H, Mehra N, Kimura A: No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations. J Infect Dis 202: 815-816, 2010.
PMID: 20684727

Nakajima T, Nakayama EE, Kaur G, Terunuma H, Mimaya JI, Ohtani H, Mehra N, Shioda T, Kimura A: Impact of novel TRIM5α variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS 23: 2091-2100, 2009.
PMID: 19710594

Nakajima T, Ohtani H, Naruse T, Shibata H, Mimaya JI, Terunuma H, Kimura A: Copy number variations of CCL3L1 and long-term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics 59: 793-798, 2007.
PMID: 17874089

Hoshino S, Sun B, Konishi M, Shimura M, Segawa T, Hagiwara Y, Koyanagi Y, Iwamoto A, Mimaya J, Terunuma H, Kano S, Ishizaka Y: Vpr in plasma of HIV type 1-positive patients is correlated with the HIV type 1 RNA titers. AIDS Research Hum Retroviruses 23: 391-397, 2007.
PMID: 17411372

照沼裕:NK細胞とHIV [NK cell and HIV]. 日本エイズ学会学会誌 [The Journal of AIDS Research] 8: 21-24, 2006.

照沼裕:アフリカ・ザンビア国のエイズの現状. 福島医学雑誌 56: 39-40, 2006.

Munkanta M, Terunuma H, Takahashi M, Hanabusa H, Miura T, Ikeda S, Sakai M, Fujii T, Takahashi Y, Oka S, Matsuda J, Ishikawa M, Taki M, Takashima Y, Mimaya J, Ito M, Kimura A, Yasunami M: HLA-B polymorphism in Japanese HIV-1-infected long-term surviving hemophiliacs. Viral Immunology 18: 500-505, 2005.
PMID: 16212528

Munkanta M, Handema R, Kasai H, Gondwe C, Deng X, Yamashita A, Asagi T, Yamamoto N, Ito M, Kasolo F, Terunuma H: Predominance of 3 NF-kB binding sites in the long terminal repeat region of HIV type 1 subtype C isolates from Zambia. AIDS Research and Human Retroviruses 21: 901-906, 2005.
PMID: 16225420

Kankasa C, Siwale M, Kasolo F, Nishiyama A, Terunuma H, Wakasugi N: Socioeconomic and reproductive factors associated with condom use within and outside of marriage among urban pregnant women in Zambia. Afr J Reprod Health 9: 128-136, 2005.
PMID: 16623197

Mitarai S, Kafwabulula LM, Habeenzu C, Terunuma H, Lubasi D, Kasolo F, Shishido H, Numazaki Y: Mycobacterium tuberculosis and gyrA variation in Zambia. Tropical Medicine and Health 33: 91-94, 2005.